Recrudescence induced by cyclophosphamide of chronic Trypanosoma cruzi infection in mice is influenced by the parasite strain
Mem. Inst. Oswaldo Cruz
;
91(1): 71-4, Jan.-Feb. 1996. tab, graf
Article
in English
| LILACS
| ID: lil-164137
ABSTRACT
Reactivation of chronic chagasic patients may occur upon of use of immunosupressive drugs related to kidney or heart transplantation or when they are affected by concomitant HIV infection. This recrudescence, however, does not occur in all chagasic patients exposed to immunosuppressive agents. We therefore investigated the influence of Trypanosoma cruzi strains in the recrudescence of the parasitism in mice at the chronic phase treated with cyclophosphamide, an immunosuppressor that blocks lymphocytes DNA synthesis and therefore controls B cells response. A large variation was detected in the percentages of newly established acute phases in the groups of mice inoculated with the different strains. We suggest that reactivation of chronic T. cruzi infections is influenced by the parasite intrinsic characteristics, a phenomenon that might occur in the human disease.
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Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
Cyclophosphamide
/
Mice
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1996
Type:
Article
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