Negative inotropic effect of chagasic IGG mediated by nitric oxide

ABSTRACT

In this paper we analyse the interaction of IgG from T. cruzi infected patients with cardiac muscarinic acetycholine receptors (mAChRs). Human chagasic IgG, activating M2 mAChR simulated the agonist actions excerting negative inotropic effect and simulation of nitric oxide synthase (NOS). Inhibitos of phospholipase C, protein Kinase C, calcium/calmodulin, NOS and guanylate cyclase activities prevented the chagasis effects upon contractility and NOS activity.