Mechanism of enhancement of renal (Na+ + K+) ATPase activity following chronic ethanol exposure
Acta physiol. pharmacol. ther. latinoam
; 46(1): 49-56, 1996. ilus, tab, graf
Article
in En
| LILACS
| ID: lil-168106
Responsible library:
BR1.1
ABSTRACT
A method was devised to determine the nature of the mechanism of the increase in renal (NA++K+)-ATPase in rats fed dilute ethanol for ten weeks. Antiserum to (NA++K+)-ATPase obtained from rabbits was added to microssomal fractions of Kidney and the activities of (NA++K+)-ATPase and Mg2+ ATPase were determined. The addition of antiserum resulted in a same pattern of dose-related inhibition of (NA++K+)-ATPase activity in control and ethanol-fed rats, whereas mg2+-ATPase was not affected by the antiserum. These results suggest that the mechanism of ethanol-induced enhancement of renal (NA++K+)-ATPase activity could be explained through an increase in the number of catalytic units.
Search on Google
Index:
LILACS
Main subject:
Sodium-Potassium-Exchanging ATPase
/
Ethanol
/
Kidney
Limits:
Animals
Language:
En
Journal:
Acta physiol. pharmacol. ther. latinoam
Journal subject:
FARMACOLOGIA
/
FISIOLOGIA
/
TERAPEUTICA
Year:
1996
Type:
Article
/
Project document