Striatal cytomegalic neurons containing nitric oxide are associated with experimental perinatal asphyxia: implication of cold treatment
Medicina (B.Aires)
;
56(2): 169-72, 1996. tab, graf
Article
in English
| LILACS
| ID: lil-172301
ABSTRACT
Neuropathological mechanisms triggered by excitatory aminoacids are Known to involve nitric oxide (NO). Neurons containing NO are histochemically reactive to nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), which labels NO synthase in CNS, Sprague-Dawley male rats subjected to perinatal asphyxia (PA) at 37 degreese Celsius, and PA plus 15 degreese Celsius hypothermia were evaluted when 6 months old by NADPH-d histochemical reaction. Computarized image analysis was used for quantification of stained sections. NADPH-d neurons in striatum from subsevere and severe PA showed a significant increment in soma size and dendritic process length versus control and hypothermic treated rats. Post-ischemic damage reurons are therefore involved in NO changes induced by PA that may be prevented by hypothermia treatment.
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Index:
LILACS (Americas)
Main subject:
Asphyxia Neonatorum
/
Corpus Striatum
/
NADPH Dehydrogenase
/
Neurons
/
Nitric Oxide
Type of study:
Risk factors
Limits:
Animals
Language:
English
Journal:
Medicina (B.Aires)
Journal subject:
Medicine
Year:
1996
Type:
Article
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