Immunological behavior in callithricidae marmosets vaccinated with a live avirulent strain of trypanosoma cruzi

RESUMO

An attempt was made to offer immunological protection against infection with virulent Trypanosoma cruzi strains to 62 marmosets belonging to the species Callithrix jacchus geoffroyi (Humboldt, 1818) and Callithrix jacchus (Linné, 1758). All results were negative, since the challenged animals showed positive parasitemia after two or more vaccinations with the PF strain, that had been shown to be avirulent and immunogenic for other laboratory animals (Menezes, 1972b). Chagas (1909) reported marmosets to be among the most sensitive animals to infection with Trypanosoma cruzi. The A. confirm this observation, but concludes that this high susceptibility of marmosets is certainly due to their immunoincompetence, as demonstrated by Harvey et al. (1974) and Gengozian et al. (1978). This must also have been the reason for the failure of the present experiment