Noncompetitive inhibitors of the acetylcholine receptor help paint a picture of its ion channel

Eterovic, Vesna A; Hann, Richard M

Eterovic, Vesna A; Hann, Richard M.

P. R. health sci. j ; 14(3): 199-209, sept. 1995.

Article in English | LILACS | ID: lil-176806

ABSTRACT

ABSTRACT

This review describes and analyzes the evidence from studies using noncompetitive inhibitors of the nicotinic acetylcholine receptor that the receptor's ion channel is formed by the second transmembrane segment of all five receptor subunits. Inconsistencies in this generally accepted model are also presented and discussed

Subject(s)

Animals; Cholinergic Antagonists/pharmacology; Ion Channels/drug effects; Receptors, Cholinergic/antagonists & inhibitors; Amino Acid Sequence; Ion Channel Gating/drug effects; Binding Sites; Ion Channels/metabolism; Cations/metabolism; Models, Chemical; Molecular Sequence Data; Neurotoxins/pharmacology; Protein Conformation; Receptors, Cholinergic/chemistry; Receptors, Cholinergic/metabolism

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Index: LILACS (Americas) Main subject: Receptors, Cholinergic / Cholinergic Antagonists / Ion Channels Limits: Animals Language: English Journal: P. R. health sci. j Journal subject: Medicine Year: 1995 Type: Article

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