Tumoral DNA analysis by flow cytometry in patients submitted to esophagectomy for squamous cell carcinoma of the esophagus

Lourenço, L. G; Laucirica, R; Del Grande, J. C; Pereira, H. F; Lechago, J; Haddad, C. M; Herbella, F. A. M

Lourenço, L. G; Laucirica, R; Del Grande, J. C; Pereira, H. F; Lechago, J; Haddad, C. M; Herbella, F. A. M.

Rev. Hosp. Säo Paulo Esc. Paul. Med ; 6(3/4): 71-4, July-Dec. 1995. tab, graf

Article in English | LILACS | ID: lil-180107

RESUMO

RESUMO

Squamous cell carcinoma of the esophagus has a poor prognosis. There are several factors influencing the prognosis. The study of DNA ploidy by flow cytometry used in many malignant tumors is very valuable in determining, as a tumor marker, this prognosis. In this study 13 cases of resected squamous cell carcinoma of the esophagus were analyzed. Despite the small sample, the authors observed that the worst prognosis was in advanced stage cases (III and IV), an aneuploid DNA pattern. The only case with a 5-year survival had a diploid DNA pattern.

Subject(s)

Humans; Male; Female; Middle Aged; Carcinoma, Squamous Cell/genetics; DNA/analysis; Flow Cytometry; Esophageal Neoplasms/genetics; Carcinoma, Squamous Cell/surgery; Diploidy; Esophagectomy; Biomarkers, Tumor/analysis; Prognosis; Retrospective Studies

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Index: LILACS (Americas) Main subject: DNA / Esophageal Neoplasms / Carcinoma, Squamous Cell / Flow Cytometry Type of study: Observational study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Rev. Hosp. Säo Paulo Esc. Paul. Med Journal subject: Medicine Year: 1995 Type: Article

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