Influence of L-triiodothyronine on rat somatotroph cells
Medicina (B.Aires)
;
56(3): 273-6, 1996. ilus, graf
Article
in English
| LILACS
| ID: lil-181484
ABSTRACT
The L-Triiodothyronine (L-T3) has a direct influence on the population of somatotrophs in rat pituitary gland. This effect is dose-dependent and induces both proliferation of somatotrophs and striking changes in the synthesis and secretion of grwth hormone (GH). Daily injections of 5 mug L-T3 for 7 days increased significantly the synthesis and storage of GH in pituitary gland, but the GH release was partially blocked. By contrast, injections of 10 mug L-T3 promote rapid synthesis and secretion of GH with removal of the cytoplasmic stores of the hormone and a consequent rise of serum levels. A close correlation was found between levels of stimulation and proliferation or retrogression of lactotroph cell population.
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Index:
LILACS (Americas)
Main subject:
Pituitary Gland
/
Triiodothyronine
/
Growth Hormone
Limits:
Animals
Language:
English
Journal:
Medicina (B.Aires)
Journal subject:
Medicine
Year:
1996
Type:
Article
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