Antiviral activity of crude extracts of Guarea guidona
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;29(5): 647-50, May 1996. tab, graf
Article
in En
| LILACS
| ID: lil-182550
Responsible library:
BR1.1
ABSTRACT
Crude extracts of leaves and fruits of Guarea guidona were tested antiviral activity against pseudorabies virus and foot-and-mouth disease virus in the IB-RS-2 pig cell line and against bovine herpesvirus-1 (BHV-1) in the GBK bovine Cell line. The highest nontoxic doses of extracts from fruits and leaves were 125 mug/ml and 500 mug/ml, respectively. Crude extracts presented antiviral activity against pseudorabies virus with a decrease in virus titer of 3.0 log units at 500 mug/ml. Virucidal activity was not observed at 62.5 mug/ml. Preformed cell monolayers showed no cytotoxic effect after 48 h in the presence of 500 mug/ml in pig cells. G. guidona leaves did not induce an antiviral state but exhibited antiviral effects during the early stage of viral infection.
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Index:
LILACS
Main subject:
Antiviral Agents
/
Plant Extracts
/
Aphthovirus
/
Herpesvirus 1, Bovine
/
Herpesvirus 1, Suid
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1996
Type:
Article