Estructura del gen del receptor de andrógeno y función de la proteína: defectos estructurales del gen que determinan resistencia a andrógenos en el hombre / Androgen receptor gene structure and protein function: structural gene defects that promote androgen resistance in man
Rev. méd. Chile
;
124(9): 1127-36, sept. 1996. ilus
Article
in Spanish
| LILACS
| ID: lil-185159
ABSTRACT
The human androgen receptor is a member of the superfamily of steroid hormone receptors and contains three functional domains an amino-terminal region involved in the expression of androgen regulated genes, a central cystein-rich DNA binding region and a carboxy-terminal hormone binding region. Proper functioning of this protein is a prerequisite for normal male sexual differentiation and development. Androgen action is currently studied in vitro, using fibroblasts culture from genital skin and complementary DNA of the androgen receptor gene has been recently cloned and sequenced. During recent years a substantial progress has been made elucidating the structure-function relationship of the androgen receptor and the characterization of the molecular defects associated with androgen insensitivity syndromes. There appears to be a broad correlation between the degree of receptor dysfunction caused by the mutation and the patient phenotype
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Index:
LILACS (Americas)
Main subject:
Disorders of Sex Development
/
Receptors, Androgen
/
Androgen-Binding Protein
Limits:
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
1996
Type:
Article
/
Project document
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