Utilidad de la inmunocitoquímica en la identificación de cuerpos de Mallory: análisis teórico de su formación / Utility of immunocytochemistry in the identification of Mallory's bodies: theorical analysis of its formation
Rev. méd. Chile
;
124(10): 1193-9, oct. 1996. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-185168
ABSTRACT
Mallory bodies are hepatocyte intracytoplasmic inclusions frequently observed in liver diseases. They contain altered intermediary filaments that have immunoreactivity with epidermic antikeratin antibodies (A-QEp). They also contain Ubiquitin (Ubq) a 76 residue polypeptide that has an important role in the proteolysis of rapid exchange and abnormal cytosol proteins. To standarize an immunohistochemical method for the detection of Mallory bodies in percutaneous liver biopsies. A-QEp and A-Ubq polyclonnal antibodies were used in the study of 131 percutaneous liver biopsies obtained from patients with different liver diseases. Mallory body immunoreactivity was confirmed with immunoelectron microscopy demonstrated that Mallory bodies are partially formed by altered intermediate filaments. In conclusion, antibodies againnst ubiquitin may be very useful for the detection of Mallory bodies in liver biopsies
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Index:
LILACS (Americas)
Main subject:
Immunohistochemistry
/
Inclusion Bodies
/
Ubiquitin
/
Keratins
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
1996
Type:
Article
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