Laminin-binding proteins in EJ-ras-transformed fibroblasts
Braz. j. med. biol. res
;
29(9): 1141-9, Sept. 1996.
Article
in English
| LILACS
| ID: lil-186124
ABSTRACT
Malignant transformation is accompanied by changes in cell-matrix interations. Upon transfection with EJ-ras oncogene, transformed fibroblasts, acquired a migratory phenotype towards laminin-1. The increase in integrin expression was responsible for the migratory activity of transformed fibroblasts. In addition alpha(6)beta(1) integrins, both galectin-3 and an unidentified laminin-binding polypeptide had their expression pattern altered upon transformation. Here, we review these two classes of laminin-binding proteins and their possible roles in cell-laminin interactions.
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Index:
LILACS (Americas)
Main subject:
Mammary Neoplasms, Animal
/
Genes, ras
/
Laminin
/
Fibroblasts
/
Lectins
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1996
Type:
Article
/
Congress and conference
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