The role of collagen in hematopoiesis
Braz. j. med. biol. res
;
29(9): 1201-7, Sept. 1996. tab
Article
in English
| LILACS
| ID: lil-186127
RESUMO
Several types of collagen, including types I, III, IV, V and VI, are produced by bone marrow stromal cells. Current information indicates that changes in collagen production result in profound alterations in the capacity of hematopoietic precursors to proliferate and differentiate. Although not definitively established, collagen molecules may be involved in the establishment and conformation of the stroma-associated extracellular matrix and/or in adhesive interactions with progenitor cells. The dynamic role of collagen in hematopoiesis is indicated by the observation that collagen production and processing are regulated by several factors such as glucocorticoids, cytokines, collagenases and collagenase-inhibitory proteins.
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Index:
LILACS (Americas)
Main subject:
Bone Marrow
/
In Vitro Techniques
/
Granulocyte Colony-Stimulating Factor
/
Transforming Growth Factor beta
/
Collagen
/
Collagenases
/
Extracellular Matrix
/
Hematopoiesis
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1996
Type:
Article
/
Congress and conference
/
Project document
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