Chemoprophylaxis in Chagas' disease: potential use of natural products of plant origin and related synthetic compounds

RESUMO

Compounds obtained from plants and by synthesis were studied as to chemoprophylaxis in Chagas' disease against bloodstream forms of trypanosoma cruzi. A broad screening was performed and some have shown trypanocidal activity as for example, claussequinone, 4-methoxy-dalbergione, deoxygoyazensolide, licnophic acid, eremantholide C, Licnopholide, ent-caur-en-19-ol and lepidine dehydrochlo-ride or WR 6026. The most active were claussequinone and lepidine.