Biological markers in suicide: one apply to medical practice

ABSTRACT

Can suicide be predicted? If we know that more than 50 per cent of suicide persons have visit a doctor before and we know probable clinic markers of suicide intent, we should look for biochemical suicide markers that have use in the medical praxis. Suicide behavior is associated mainly to alterations of the serotoninergic system. The most consistent indicator of suicide risk in the history in course is the metabolism of the serotonine, 5HIAA, mainly in the CSF, also can be use like helpers in the increase of the urinal 17 hidrocortizone, the increase of plasmatic cortisol higher than 20mcg per cent, positivity of the dexametazone suppression test, the answer of TSH to TRH, the latency of REM increase in the electroencephalogram of sleep and seric cholesterol decrease. Perhaps all this investigations in the biochemical of suicide have a little application in medicine. That's why we make a revision in the principal and probable suicide biologic markers and we intent to help in the search of one that have application in the medical praxis, like cholesterol. We are doing a investigation work between cholesterol association, suicide behavior and depression, based in the serotoninergic hypothesis of suicide etiopathogeny.