Does plasma ANP participate in natriuresis induced by alpha-MSH?
Braz. j. med. biol. res
;
30(4): 459-63, Apr. 1997. tab, graf
Article
in English
| LILACS
| ID: lil-191383
ABSTRACT
Alpha-Melanocyte-stimulating hormone (alpha-MSH;0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of alpha-MSH (3 and 9.6 nmol) induced a significant increase urinary sodium, potassium and water excretion. Intraperitoneal (3 and 4.8 nmol) or iv (3 and 9.6 nmol) administration of alpha-MSH did not induce any significant changes in plasma atrial natriuretic peptide (ANP), suggesting that the natriuresis, kaliuresis and diuresis induced by the systemic action of alpha-MSH can be dissociated from the increase in plasma ANP. These preliminary results suggest that alpha-MSH may be involved in a gamma-MSH-independent mechanism of regulation of hydromineral metabolism.
Full text:
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Index:
LILACS (Americas)
Main subject:
Alpha-MSH
/
Cerebral Ventricles
/
Atrial Natriuretic Factor
/
Diuresis
/
Natriuresis
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1997
Type:
Article
/
Congress and conference
/
Project document
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