Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of cabachol
Braz. j. med. biol. res
;
30(4): 493-6, Apr. 1997. graf
Article
in English
| LILACS
| ID: lil-191387
ABSTRACT
We investigated the effects of losartan, an AT1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l mul) into the LV blocked the pressor response induced by ANG II (12 ng/1 mul) and carbachol (2 nmol/ 1 mul). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 + 1 and 28 + 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 + 1 and 5 + 2 mmHg, respectively). The injection of ramipril (12 ng/ 1 mul) prior to carbachol blocked the pressor effect of carbachol to 7 + 3 mmHg. These results suggests an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure.
Full text:
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Index:
LILACS (Americas)
Main subject:
Pressoreceptors
/
Renin-Angiotensin System
/
Blood Pressure
/
Carbachol
/
Receptors, Angiotensin
/
Angiotensin-Converting Enzyme Inhibitors
/
Cerebral Ventricles
/
Ramipril
/
Cholinergic Agonists
/
Imidazoles
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1997
Type:
Article
/
Congress and conference
/
Project document
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