Evidentiation of paramyosin (Sm-97) as a modulating antigen on granulomatous hypersensitivity to Schistosoma mansoni eggs
Mem. Inst. Oswaldo Cruz
;
92(5): 663-7, Sept.-Oct. 1997. ilus
Article
in English
| LILACS
| ID: lil-194213
ABSTRACT
A Schistosoma mansoni adult worm anionic fraction (PIII) has previously been shown to protect mice against challenge infection and to reduce pulmonary and hepatic granulomatous hypersensitivity. Serum from PIII-immunized rabbit was used to screen a gt11 cDNA library from S. mansoni adult worm in order to identify antigens capable of modulating granulomatous hypersensitivity. We obtained four clones with 400 (Sm-III.11), 900 (Sm-III.16), 1100 (Sm-III.10) and 1300 (Sm-III.12) bp of length. All clone-specific antibodies were able to recognize most of the PIII components. The sequence analysis showed that these clones presented high homology with S. mansoni paramyosin (Sm-97). These findings describe a new function to this antigen with an important role in modulation of granulomatous hypersensitivity to S. mansoni eggs.
Full text:
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Index:
LILACS (Americas)
Main subject:
Schistosoma mansoni
/
Tropomyosin
/
Antigenic Modulation
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1997
Type:
Article
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