Hormonas vasodilatadoras en la insuficiencia cardíaca crónica: efecto de la inhibición de la enzima convertidora de angiotensina / Vasodilator hormones in chronic heart failure: effect of the inhibition of angiotensine converting enzyme
Rev. méd. Chile
;
125(2): 135-42, feb. 1997. tab, graf
Article
in Spanish
| LILACS
| ID: lil-194810
ABSTRACT
To evaluate the chronic effect of enalapril, in addition to digitalis and diuretics, in patients with chronic heart failure, nine patients with an idopathic dilated cardiomyopathy (8 males, aged 48 to 76 years old) under treatment with digitalis and diuretics, received enalapril 20 mg bid during eigth weeks. Before and after this treatment period resting left ventricular ejection fraction, functional class, plasma levels of atrial natriuretic factor and bradykinins (BK) and urinary excretion of kalikreins (BK) and prostaglandins E2 (PGE2) were measured. After enalapril therapy, there was a significant increase in maximal O2 consumption (14.8ñ1.2 to 18.6ñ1.5 ml/kg/min, p<0.05) and radionuclide LV ejection fraction (27.4ñ1.1 to 31.4ñ0.9 percent p<0.05). This was associated with a significant decrease in plasma ANP levels (559ñ158 to 178ñ54.8 pg/ml) and UK (391ñ112 to 243ñ92 Cu/24 h). The decrease in ANP levels, which is a well known marker of prognosis in CHF, could contribute to explain the sustained clinical benefits observed with ACE inhibitors in patients with CHF
Search on Google
Index:
LILACS (Americas)
Main subject:
Angiotensin-Converting Enzyme Inhibitors
/
Heart Failure
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
1997
Type:
Article
Similar
MEDLINE
...
LILACS
LIS