On the purinergic regulation of hormonal secretion from the anterior pituitary gland
Rev. bras. biol
;
56(supl.1,pt.2): 369-72, dez. 1996.
Article
in English
| LILACS
| ID: lil-196353
ABSTRACT
Purinergic regulation of hormonal secretion from the anterior pituitary may be characterized by effects with biphasic secretory response. This response may be started by activation of different subtypes of membrane prurinergic receptor (A1 and/or A2). A putative autocrine mechanism has been proposed to explain the action of adenosine on pituitary hormonal secretion. This mechanism may be dependent on adenosine degradation by the enzyme adenosine deaminase into the extracellular space. The regulation of AMPc and calcium levels in cytoplasm may be part of putative intracellular mechanisms involved in purinergic action. Additionally, hypophysiotrophic effects induced by hypothalamic substances may be modulated by adenosine. The mechanisms involved in this modulatory effects, however, remain elusive.
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Index:
LILACS (Americas)
Main subject:
Pineal Gland
/
Receptors, Purinergic
Language:
English
Journal:
Rev. bras. biol
Journal subject:
Biology
Year:
1996
Type:
Article
/
Congress and conference
/
Project document
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