Progression of nephropathy after islet of langerhans transplantation in alloxan-induced diabetic rats
Acta cir. bras
;
12(1): 16-22, jan.-mar. 1997. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-197661
ABSTRACT
We studied the effects of islet of Langerhans transplantation (IT) on the kidney lesions of rats with alloxan-induced diabetes. Forty-five inbred male Lewis rats were randomly assigned to 3 experimental groups group GI incliuded 15 non-diabetic control rats. (NC), group GII included 15 alloxan-induced diabetic rats (DC), and group III included 15 alloxan-induced diabetic rats that received pancreatic islet transplantation prepared by nonenzymatic method from normal donor Lewis rats and injected into the portal vein (IT). Each group was further divided into 3 subgroups of 5 rats which were sacrificed at 1, 3 and 6 months of follow-up, respectively. Clinical and laboratorialparameters were recorded in the mentioned periods in the 3 experimental groups. For histology, the kidneys of all rats of each subgroup were wtudied and 50 glomeruli and 50 tubules of each kidney were analyzed using light microscopy by two different investigators in a double blind study. The results showed progressive glomerular basement membrane thickening (GBMT), mesangial enlargement (ME),and Bowman's capsulethickening (BCT) in the 3 experimental groups throughout the follow-up...
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Islets of Langerhans Transplantation
/
Diabetic Nephropathies
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
1997
Type:
Article
/
Congress and conference
Similar
MEDLINE
...
LILACS
LIS