Bioequivalence study for diazepam commercial tablets in psychiatric patients
Arch. med. res
;
25(1): 23-7, 1994. tab, ilus
Article
in English
| LILACS
| ID: lil-198799
RESUMO
The bioequivalence of three different commercial diazepan tablets (5mg) using the innovator product (Valium, Roche) as a reference was evaluated in eight psychiatric patients, following a multiple-dose regimen (5 mg t.i.d.). Each patient receive the four treatments sequentially according to a Latin square design, with balance for first residual effect. Blood samples were taken once the steady state of the drug had been reached, and the plasma levels were determined using a HPLC method. No statistical differences were found in diazepam steady-state levels after the adminsitration of the four formulations, indicating that they could be aconsidered equivalent
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Index:
LILACS (Americas)
Main subject:
Plasma Volume
/
Psychiatry
/
Therapeutic Equivalency
/
Diazepam
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Arch. med. res
Journal subject:
Medicine
Year:
1994
Type:
Article
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