Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain / Reducción de los receptores glicinérgicos insensibles a estricnina en el globo pálido del cerebro de ratones intoxicados con manganeso

ABSTRACT

Manganese (Mn) poisoning is characterized by central nerous system manifestations, including psychiatric disturbances and estrapyramidal disorders. This metal is thought to produce neuronal degeneration due to cytotoxic products originated by oxidative stress and through an indirect excitotoxic process. In previous studies, we have found a reduction in the density of N-methyl-D-aspartate (NMDA) recognition sites in some brain areas of Mn-treated mice. Due to the close relationship between NMDA receptor complex, the [3H]-glycine ([3H]/Gly) binding was manganese choride for 8 weeks. Among all analyzed areas, only the globus pallidus showed a significant reduction in [3H]-Gly binding (27-28). The Gly binding decrease, focalized in the globus pallidus, could reflect a degeneration of structures containing strychnine-insensitive Gly receptors, since this area is the most frequently reported damaged brain region in Mn intoxication. Howerer, it might also be due to a Gly receptor down-regulation to control NMDA complex activation during Mn poisoning.