Reduction of post-prandial motility by pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract in patients with irritable bowel syndrome
Acta gastroenterol. latinoam
;
27(4): 247-51, 1997. ilus
Article
in English
| LILACS
| ID: lil-200084
RESUMO
Background:
Growing evidence points to irritable bowel syndrome physiologically as a disease of the enteric nervous system characterised by hypermotility. The aim of this study was to investigate the action of pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract on basal and post-prandial recto-anal motility of 40 irritable bowel syndrome patients in a random, double blind and placebo controlled trial.Methods:
Pinaverium bromide (50 mg) or placebo was taken orally t.i.d with food. Myoelectrical and mechanical activities of the rectum and the internal anal sphincter were recorded before treatment for 2 h in the fasting state and for an additional 2 h post-prandial.Results:
Post-prandial rectal spike amplitude and frequency as well as the spontaneous recto-anal inhibitory reflex frequency decreased after pinaverium bromide (P < 0.01) but not after placebo.Conclusions:
These results suggest that the calcium channel blockers acting selectively on the gastrointestinal tract may have a therapeutic role in patients with irritable bowel syndrome.
Search on Google
Index:
LILACS (Americas)
Main subject:
Rectum
/
Calcium Channel Blockers
/
Morpholines
/
Colonic Diseases, Functional
/
Gastrointestinal Motility
Type of study:
Controlled clinical trial
Limits:
Adolescent
/
Adult
/
Female
/
Humans
Language:
English
Journal:
Acta gastroenterol. latinoam
Journal subject:
Gastroenterology
Year:
1997
Type:
Article
Similar
MEDLINE
...
LILACS
LIS