Pharmacokinetics of oral ranitidine in Mexicans
Arch. med. res
;
27(3): 349-52, 1996. tab, ilus
Article
in English
| LILACS
| ID: lil-200335
RESUMO
The pharmacokinetics of oral ranitidine were studied in 24 Mexican male healthy volunteers. Subjects received a tablet containing 150 mg of ranitidine (Azantac TM, Glaxo de Mexico, Mexico, City) after an overnight fast and blood samples were drawn at several times for a period of 24 h. Ranitidine concentration in plasma was measured by high performance liquid chromatography and pharmacokinetic parameters were determined by non-compartmental analysis. Ranitide plasma concentration increased with time, reaching a maximum of (mean ñ SEM) 484 ñ 34 ng/ml in 2.7 ñ 0.2 h. Plasma levels then decayed with a terminal half-life of 4.8 ñ 0.3 h. The area under the plasma concentration against time curve was 2440 ñ 126 ngh/ml. Oral ranitidine pharmacokinetic parameters in mexicans appeared to be similar to those previously reported for caucasians
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Index:
LILACS (Americas)
Main subject:
Plasma
/
Ranitidine
/
Pharmacokinetics
/
Chromatography
/
Nizatidine
/
Methylene Chloride
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
English
Journal:
Arch. med. res
Journal subject:
Medicine
Year:
1996
Type:
Article
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