Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods
São Paulo med. j
;
115(4): 1471-4, jul.-ago. 1997. tab
Article
in English
| LILACS
| ID: lil-208784
RESUMO
Alternatives to the traditional hormone receptor dosages for prognostic evaluation and clinical approach to breast cancer have been proposed for immunohistochemical determinations. For correlation purposes, such procedures were compared in 37 patients presenting 5 to 15 years of survival. Considering 30 fm/mg as the positivity index, the disagreement between both methods reached 35.1 percent with estrogen and 48.5 percent with progesterone receptors. When the positiveness level was changed to 20 fm/mg, the discrepancies were reduced to 32 percent with ER and increased to 57 percent with PgR. This study leads us to not recommend the immunohistochemical method applied to paraffin sections as an alternative procedure to the dextran-charcoal dosage for prognosis and therapeutic management of mammary carcinoma.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Breast Neoplasms
/
Immunohistochemistry
/
Receptors, Progesterone
/
Receptors, Estrogen
Type of study:
Prognostic study
/
Qualitative research
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
1997
Type:
Article
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