Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy
São Paulo med. j
;
115(4): 1485-9, jul.-ago. 1997. tab, graf
Article
in English
| LILACS
| ID: lil-208786
RESUMO
An inhibitory serum factor of mixed lymphocyte culture (MLC) has been associated with successful pregnancy after lymphocyte transfusion in women with unexplained recurrent spontaneous abortions (RSA). Objective:
Investigate whether the inhibitory serum factor of MLC is essential for a successful pregnancy.Method:
Sera from 33 healthy pregnant women and from 40 women with RSA were assessed by a one-way MLC in which the woman's lymphocytes were stimulated with her partner's lymphocytes or with third party lymphocytes.Results:
An inhibitory serum effect (inhibition >50 percent as compared to normal serum) was detected in 45 percent of the pregnant women who had at least 1 previous parity, in 8 percent of the primigravidea, in 29 percent of those with one abortion and in 58 percent of those with more than one abortion.Conclusion:
MLC inhibitory serum factor does not seem to be an essential factor for pregnancy development. Therefore, it should not be considered as a parameter for the assessment of RSA patients.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Blood
/
Lymphocytes
/
Abortion, Habitual
/
Lymphocyte Culture Test, Mixed
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
1997
Type:
Article
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