Cross-reactivity of anti-10kD heat shock protein antibodies in leprosy and tuberculosis patients
Medicina (B.Aires)
;
57(5): 581-6, 1997. graf, tab
Article
in English
| LILACS
| ID: lil-209685
RESUMO
The response to recombinant 10-KD heat shock protein (HSP of Mycobacterium leprae (rML10) was evaluated by indirect ELISA in sera from leprosy patients, household contacts, tuberculosis patients and healthy controls a leprosy-endemic area in tne North East of Argentina. Some technical parameters were a analyzed within-assay and between-assay variability, dose-response curves and dectability indexed (specificity and sensitivity) of ELISA applied to measure anti-10kDa antibodies. High levels of these antibodies have already been reported in positive baciloscopy patients; herein we have also demonstrated that tuberculosis patients sera cross-react with this M. leprae antigen. This test seems to have a low sensificity for leporsy detection; it confirms that antibodies against highly conserved HSP antigens are important in the polycional response against mycobacterial epitopes in leprosy as well as in tuberculosis.
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Index:
LILACS (Americas)
Main subject:
Tuberculosis
/
Chaperonin 10
/
Leprosy
/
Antibodies, Bacterial
/
Mycobacterium leprae
/
Antigens, Bacterial
Type of study:
Diagnostic study
Limits:
Adult
/
Aged80
/
Humans
Language:
English
Journal:
Medicina (B.Aires)
Journal subject:
Medicine
Year:
1997
Type:
Article
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