Inmunodiagnóstico en 647 casos clínicos sospechosos de toxoplasmosis / Immunodiagnosis in 647 clinical cases of toxoplasmosis suspected

RESUMO

Though Toxoplasma gondii can cause severe pathology in human, in most of the cases it asymptomatic infection. So, it is important to dispose some methods capables to discriminate and chronic infections. An indirect hemagglutination test (IHAT), dye test (DT) and complement fixation test (CFT) were performed in 647 sera from patients suspected of having toxoplasmosis infection. IHAT and DT titer > the same as 4 and CFT > the same as 5 were considered positive. Titers were classified as follows low (4-16), median (64-512) and high (> the same as 1000) for IHAT and DT. The pathologies for demanding these serological tests were adenopathies (58), nephropathies (72), neuropathies (30), obstetrical problems (65), opthalmopathies (147), AIDS (237) and miscellaneous (37). Global positvity of 49.5 percent and 4.5 percent for IHAT/DT and CFT respectively were found. The positvity for the different groups were adenopathies (48.3 percent and 13.8 percent), nephropathies (43.1 percent and 1.4 percent), neuropathies ,(26.7 percent and 3.3 percent), obstetrical problems (40.0 percent and 0.0 percent), ophthalmopathies (59.9 percent and 8.2 percent), AIDS (52. 1 percent and 2.5 percent) and miscellancous (40.5 percent and 2.7 percent) for IHAT/DT and CFT respectively. Low and median titers for IHAT/DT were found in 81.3 percent of cases. A high agreement in frequency of concordant and discordant titers of IHAT/DT and CFT, indicating a recent or acute infection was observed. This fact was more relevant in adenopathies, ophthalmopathies (uveitis) and AIDS groups