A possible defective estimation of antineutrophil cytoplasmic antibodies in systemic lupus erythematosus due ot the coexistence of periodontitis: preliminary observations
P. R. health sci. j
;
16(4): 369-73, Dec. 1997. tab, graf
Article
in English
| LILACS
| ID: lil-212072
ABSTRACT
The objectives of this study is to determine if periodontitis-related ANCA hinder the accurate estimation of this kind of autoantibodies in systemic lupus erythematosus (SLE), due to the frequent coexistence of SLE and periodontitis, and the high incidence of antineutrophil cytoplasmic antibodies (ANCA) in this periodontal condition. Thirty SLE, thirty periodontitis lacking systemic involvement patients, and twenty healthy controls were utilized in this study. The periodontal condition and the presence of ANCA in sera of all individuals was carefully evaluated. For ANCA determination an EIA essay was utilized, directed to a neutrophil granular extract and six neutrophil granule proteins. Sixty percent of SLE patients had periodontitis, and sixty-five percent were ANCA positive. Eighty three percent of all ANCA cases were coexisting with periodontitis. A significant association (p > 0.005) between periodontitis and ANCA was found (Chi Square Test). Fifty percent of the patients with periodontitis lacking systemic involvement were ANCA positive. The results obtained in this study suggest that the figures of ANCA previously reported for SLE, might be overestimated due to the inadvertent presence of periodontitis
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Index:
LILACS (Americas)
Main subject:
Periodontitis
/
Antibodies, Antineutrophil Cytoplasmic
/
Lupus Erythematosus, Systemic
Type of study:
Diagnostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
P. R. health sci. j
Journal subject:
Medicine
Year:
1997
Type:
Article
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