Interruption of recently induced immune responses by oral administration of antigen
Braz. j. med. biol. res
;
31(3): 377-80, Mar. 1998. graf
Article
in English
| LILACS
| ID: lil-212273
RESUMO
Interest in oral tolerance has been renewed in the last few years as a possibility of intervention in human autoimmume diseases. An obstacle in this direction in that, although easily induced in animals virgin of contact with the antigen, oral tolerance becomes hard to induce in previously immunized animals. The present results show that there is an early period after primary immunization in which prolonged oral exposure to the antigen may arrest ongoing immune responses. Beyond this period, oral exposures to the antigen become ineffective and may actually boost immune responses. The end of the susceptible period coincides with the emergence of free specific antibodies in serum. However, the previous administration of purified anti-ovalbumin antibodies (40 mug) was unable to block the induction of oral tolerance to ovalbumin in normal mice.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Autoimmune Diseases
/
Desensitization, Immunologic
/
Antibody Formation
/
Antigens
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1998
Type:
Article
/
Project document
Similar
MEDLINE
...
LILACS
LIS