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Eosinophil-active chemokines: assessment of in vivo activity
Braz. j. med. biol. res ; 31(1): 19-24, Jan. 1998. ilus, tab
Article in English | LILACS | ID: lil-212537
ABSTRACT
The selective recruitment of eosinophils in tissue is a striking feature of allergic diseases. Recently, a family of chemoattractant molecules, namely chemokines, has been described which potently activates eosinophil function in vitro. We have developed a murine model of eosinophil recruitment to compare the relative potency and efficacy of chemokines in vivo. Of the chemokines tested, only eotaxin and MIP-1alpha induced significant accumulation of eosinophils in vivo, but eotaxin was more effective than MIP-1alpha. Chemokines, especially eotaxin acting via the CCR-3 receptor, may have a fundamental role in determining selective eosinophil recruitment in vivo.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Chemokines / Eosinophils Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1998 Type: Article / Congress and conference

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Full text: Available Index: LILACS (Americas) Main subject: Chemokines / Eosinophils Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1998 Type: Article / Congress and conference