Eosinophil-active chemokines: assessment of in vivo activity
Braz. j. med. biol. res
;
31(1): 19-24, Jan. 1998. ilus, tab
Article
in English
| LILACS
| ID: lil-212537
ABSTRACT
The selective recruitment of eosinophils in tissue is a striking feature of allergic diseases. Recently, a family of chemoattractant molecules, namely chemokines, has been described which potently activates eosinophil function in vitro. We have developed a murine model of eosinophil recruitment to compare the relative potency and efficacy of chemokines in vivo. Of the chemokines tested, only eotaxin and MIP-1alpha induced significant accumulation of eosinophils in vivo, but eotaxin was more effective than MIP-1alpha. Chemokines, especially eotaxin acting via the CCR-3 receptor, may have a fundamental role in determining selective eosinophil recruitment in vivo.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Chemokines
/
Eosinophils
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1998
Type:
Article
/
Congress and conference
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