Genomic and phylogenetic analysis of hapatitis C virus strains from Argentina
Medicina (B.Aires)
;
58(2): 153-9, 1998. tab, graf
Article
in English
| LILACS
| ID: lil-212787
ABSTRACT
HCV genomic characterization was performed by nucleotide sequence analysis (n=50) combined with restriction fragment length polymorphism (RFLP) of the 5'UTR region in 82 isolates coresponding to different Argentine groups. Genotype 1 was detected in 70.7 percent of the samples (58 out of 82), genotype 2 in 21.9 percent (18 of 82) and genotypes 3 in the remaining 6 sera (7.3 percent). HCV ib subtype contributed with 35.3 percent to the whole population studied (29 of 82) and was detected in 6 out of 21 sporadic cases. Besides their epidemiological significance, these results should be taken into account when future vaccines are considered on the basis of geographical HCV genotypic prevalence.
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Index:
LILACS (Americas)
Main subject:
Phylogeny
/
Polymorphism, Restriction Fragment Length
/
Hepacivirus
/
Hepatitis C, Chronic
Type of study:
Etiology study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
Country/Region as subject:
South America
/
Argentina
Language:
English
Journal:
Medicina (B.Aires)
Journal subject:
Medicine
Year:
1998
Type:
Article
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