Ketoconazole-induced liver damage
Medicina (B.Aires)
;
58(3): 277-81, 1998. ilus
Article
in English
| LILACS
| ID: lil-213402
RESUMO
Five cases (four females, one male) of ketoconazole-related liver damage are presented, two of whom died. All patients received ketoconazole (400 mg/day) for various mycoses. In the four women the first signs of hepatotoxicity appeared after four weeks of therapy. One fatal case developed massive necrosis with fulminant liver failure and the other, submassive necrosis. In four cases cholestasis was a prominent finding. Biochemical evidence of biliary stasis may persist for several months, as occurred in the three surviving patients of our series. The two fatal cases continued receiving the drug in spite of its adverse effects. Consequently, repeated evaluation is recommended to detect early signs of liver involvement.
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Index:
LILACS (Americas)
Main subject:
Ketoconazole
/
Liver Diseases
/
Antifungal Agents
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Medicina (B.Aires)
Journal subject:
Medicine
Year:
1998
Type:
Article
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