The use of non-human primates as animal models for the study of hepatitis viruses
Braz. j. med. biol. res
;
31(8): 1035-48, Aug. 1998. tab
Article
in English
| LILACS
| ID: lil-216826
ABSTRACT
Hepatitis viruses belong to different families and have in common a striking hepatotropsin and restrictions for propagation in cell culture. The transmissibility of hepatitis is in great part limited to non-human primates. Enterically transmitted hepatitis viruses (hepatitis A virus and hepatitis E virus) can induce hepatitis in a number of OLD World and New Worls monkey species, while the host range of non-human primates susceptible to hepatitis viruses transmitted by the parenteral route (hepatitis B virus, hepatitis C virus and hepatitis delta virus) is restricted to few species of Old World monkeys, especially the chimpanzee. Experimental studies on non-human primates have provided an invaluable source of information regarding the biology and pathogenesis of these viruses, and represent a still indispensable tool for vaccine and drug testing.
Full text:
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Index:
LILACS (Americas)
Main subject:
Cebidae
/
Cercopithecidae
/
Disease Models, Animal
/
Hepatitis, Viral, Animal
/
Hepatitis Viruses
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1998
Type:
Article
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