The spleen is an important site of T cell activation during human hepatosplenic schistosomiasis
Mem. Inst. Oswaldo Cruz
;
93(supl.1): 159-64, Oct. 1998. tab
Article
in English
| LILACS
| ID: lil-218658
ABSTRACT
We have undertaken a comparative immunephenotypic study of spleen cells from hepatosplenic patients (HS) and uninfected individuals (NOR) using flow cytometry. Our data did not show any significant differences in the mean percentage of T-cells and B-cells between the two groups. Analysis of activated T-cells demostrated that HS present an increased percentage of CD3+HLA-DR+ splenocytes in camparasion to NOR. Analysis of T-cell subsets demostrated a significant increase on the percentage of both activated CD4+T-splenocytes and CD8+cells in HS. We did not find any difference in the mean percentage of CD28+T-cells. Analysis of the B-cell compartament did not show any difference on the percentage of B1-splenocytes. However, the spleen seems to be an important reservoir/source for B1 lymphocytes during hepatosplenic disease, since after splenectomy we found a decrease on the percentage of circulating B1-lyphocytes. We observed an increase on the percentage of CD2+CD3-lymphocytes in the spleen of HS suggesting that the loss of CD3 by activated T-cells or the expansion of NK-cells might play a role in the development/maintenance of splenomegaly.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Schistosomiasis
/
Spleen
/
Splenic Diseases
/
Splenomegaly
/
T-Lymphocytes
/
Liver Diseases, Parasitic
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1998
Type:
Article
/
Congress and conference
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