Effects of chronic infusion of nerve growth factor (NGF) in rats with nucleus basalis magnocellularis lesion
La Habana; s.n; 1996. 4 p. tab, graf.
Non-conventional
in English
| LILACS
| ID: lil-223657
RESUMO
We attempted to evaluate the effects of bilaeral injection of ibotenic acid (IA) into the nucleus basalis magnocelluraris (rbm) of rats as well as the potential recovery mediated by the infusion of nerve growth factor (NGF). The lesion caused and impairment of learning and memory processes. Also, a severe depletion of choline acetyl transferase activity was detected in cortical areas. After the NGF administration, a significant reversion of these functional changes was observed. Thus, IA-lesioned rats might serve as a model for the evaluation of neurotrophic factors actions on basal forebrain damaged neurons
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Index:
LILACS (Americas)
Main subject:
Rats
/
Substantia Innominata
/
Cognition
/
Ibotenic Acid
/
Nerve Growth Factors
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Year:
1996
Type:
Non-conventional
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