Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts
Braz. j. med. biol. res
;
31(12): 1557-64, Dec. 1998. tab
Article
in English
| LILACS
| ID: lil-224841
RESUMO
Human subjects with active vulgar vitiligo do not respond well to autologous dermo-epidermal minigrafting. Eighteen subjects were treated with the FACE="Symbol">a-melanocyte-stimulating hormone (FACE="Symbol">a-MSH) synthetic analogue [Nle4, D-Phe7]-FACE="Symbol">a-MSH. The hormone (50 µl, 0.4 mM) was applied topically to 30-cm2 lesions in which 29-48 minigrafts had been made. The hormone did not improve the success of the minigrafting and no differences were observed in local or distant repigmentation in treated subjects as compared to the placebo group. Aliquots of 24-h urine concentrated by lyophilization irreversibly darkened toad skins, demonstrating the presence of the analogue. This is the first report of the transdermal delivery of a topically applied melanotropin in living human subjects:
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vitiligo
/
Alpha-MSH
/
Skin Transplantation
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1998
Type:
Article
Affiliation country:
Brazil
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