In vivo metabolism of alpha-tocopherol in lipoproteins and liver: studies on rabbits in response to acute cholesterol loading
São Paulo med. j
;
116(4): 1753-9, jul.-ago. 1998. tab, graf
Article
in English
| LILACS
| ID: lil-224903
ABSTRACT
Objective:
To investigate the transport of alpha-tocopherol in lipoproteins of rabbits under normal diet and under acute loading of cholesterol.Design:
Two New Zealand White rabbits were fed (14)C-alpha-tocopherol acetate in a single oral dose and the recovery of radiolabel in lipoproteins and plasma was monitored. Low density lipoprotein (LDL) from these animals was obtained and labeled with [(3H)] cholesteryl ester. Three other rabbits were injected with this double-labeled LDL in the native form; while three other animals received this LDL in the acetylated form.Results:
Plasma clearance, live uptake and levels of radiolabel in high dinsity lipoprotein (HDL) of animals injected with (14)C[(3H)]acetyl LDL were significantly higher than those in animals injected with (14)C[(3H)] native LDL. Larger particles of HDL, rich in apolipoprotein E (apoE) carried significantly higher levels of both labels in rabbits injected with acetylated LDL.Conclusion:
These results provide evidence for in vivo mechanisms of "reverse alpha-tocopherol transport", analogous to "reverse cholesterol transport".
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vitamin E
/
Cholesterol
/
Lipoproteins
/
Liver
Limits:
Animals
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
1998
Type:
Article
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