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Asymmetrical effects of the unilateral implant of pilocarpine on the preoptic-anterior hypothalamic area on spontaneous ovulation of the adult rat
Arch. med. res ; 28(3): 343-8, sept. 1997. tab
Article in English | LILACS | ID: lil-225238
ABSTRACT
The effects on ovulation at the next strus after unilaterally implanting pilocarpine in the preoptic-anterior hypothalamic area (POA-AHA) of rats on each day of the estrous cycle were analyzed. Implantation on the left side of POA-AHA on the day of estrus blocked ovulation in all animals, whereas implantation on the right side did not (0/5 vs. 4/4, p<0.05). Implantation on diestrus 1 or 2 on either side of the POA-AHA blocked ovulation. Implatation on the righ side of the POA-AHA at the day of proestrus blocked ovulation (1/6 animals ovulated), while 10/12 with pilocarpine on the left side ovulated (p<0.05).The administration of 3.7 µg of GnRH at 1300 h o the expected day of proestrus induced ovulation in 36/42 treated animals. In rat with a pilocarpine implant, the injection of estradiol benoznate on diestrus 2 restored ovulation only in those animals with the pilocarpine implant placed in the left side of the POA-AHA, performed on the day of estrus. The results support the previous estatements that in the adult rat POA-AHA, the cholinergic mechanism regulating preovulatory GnRH release, is lateralized. In addition, at the beginning of the estrous phase, the PAO-AHA-cholinergic system needs to remain undisturbed for normal ovulation to take place at the next estrus
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Index: LILACS (Americas) Main subject: Ovulation / Pilocarpine / Preoptic Area / Rats, Inbred Strains / Muscarinic Agonists / Anterior Hypothalamic Nucleus Limits: Animals Language: English Journal: Arch. med. res Journal subject: Medicine Year: 1997 Type: Article

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Index: LILACS (Americas) Main subject: Ovulation / Pilocarpine / Preoptic Area / Rats, Inbred Strains / Muscarinic Agonists / Anterior Hypothalamic Nucleus Limits: Animals Language: English Journal: Arch. med. res Journal subject: Medicine Year: 1997 Type: Article