Induction of acute and chronic pancreatitis with the use of the toxin of the scorpion Tityus serrulatus: experimental model in rats
Arq. gastroenterol
;
35(3): 216-22, jul.-set. 1998. ilus, tab
Article
in English
| LILACS
| ID: lil-225368
ABSTRACT
We observed that the purified venom of the Tityus serrulatus scorpion (T1 fraction), injected IV in rats, in a single dose of 0,5 mg/kg, produces acute pancreatitis, characterized by degranulation and acinar cell vacuolization, necrosis and an inflammatory reaction, 24, 48 and 96 hours after the injection; chronic pancreatitis, characterized by interstitial fibrosis, lymphocyte infiltration, ductal and ductular dilation, acinar cell atrophy, periductal ductular hyperplasia, 20 days after injection; hyperplasia of Langerhans' islets and nesidioblastosis, associated to chronic pancreatitis. The absence of deaths in the experimental group is an intersting finding:
the dose used preserved the animals from death and allowed the safe follow-up ot the progression of the provoked pancreatitis. The results led us to conclude that the toxin of Tityus serrulatus scorpion is an agent of considerable efficacy in the induction of pancreatitis in rats providing an experimental model of acute and chronic form of this disease.
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Index:
LILACS (Americas)
Main subject:
Pancreatitis
/
Scorpion Venoms
/
Toxins, Biological
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Arq. gastroenterol
Journal subject:
Gastroenterology
Year:
1998
Type:
Article
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