Alterations in kidney enzyme pattern in acute hypervitaminosis A
Arch. latinoam. nutr
;
48(2): 129-33, jun. 1998. tab
Article
in English
| LILACS
| ID: lil-226051
RESUMO
The relation of excessive doses of vitamin A with various kidney pathologies is well known however, information concerning the relation of kidney enzyme activity with acute hypervitaminosis A is rather scarce. In this study we describe the kidney enzymatic alterations observed in rats that received daily intramuscular injectiosn of 10.000, 30.000, 50.000 and 100.000IU of vitamin A palmitate (VA) during seven days (TREATED GROUPS). A comparison is made with the enzyme activity in healthy rats pairfed and treated with sodium palmitte by intramuscular injection (CONTROL GROUP). The treated rats showed a proportional increase (<0.05) in activity of acid maltase, transaminases or aminotransferase (GOT and GPT), alkaline phosphatase (ALP) and acid protease with all doses of VA administered, Amylase, lipase and arginase tend to decrease (p<0.05) in activity only with doses of 50.000 and 100.000 I.U. of VA. Several factors are responsible for these findings, such as kidney necrosis due to release of lysosomal acid hydrolases produced by hypervitaminosis A.
Search on Google
Index:
LILACS (Americas)
Main subject:
Aspartate Aminotransferases
/
Hypervitaminosis A
/
Alanine Transaminase
/
Hydrolases
/
Kidney
Limits:
Animals
Language:
English
Journal:
Arch. latinoam. nutr
Journal subject:
Bioqu¡mica
/
EducaÆo Alimentar e Nutricional
/
Fenmenos Fisiol¢gicos da NutriÆo
/
Microbiologia de Alimentos
/
NUTRICAO
Year:
1998
Type:
Article
Similar
MEDLINE
...
LILACS
LIS