Cholesterol-lowering effects of policosanol in rabbits
Biol. Res
;
27(3/4): 205-8, 1994. tab, graf
Article
in English
| LILACS
| ID: lil-228580
ABSTRACT
Policosanol is a natural mixture of higher primary aliphatic alcohols isolated and purified from sugar cane (Saccharum officinarum, L.) wax, whose main component is octacosanol. Policosanol (5-200 mg/kg) orally administered for 4 weeks to normocholesterolemic New Zealand rabbits significantly reduced total cholesterol and low density lipoprotein cholesterol (LDL-C) serum levels in a dose dependent manner. Serum triglyceride levels of treated and control animals were significantly different, but the reduction observed was not dose-dependent. High density lipoprotein cholesterol (HDL-C) levels remained unchanged. Results indicate that the reduction in total cholesterol values induced by policosanol is mainly mediated through a decrease in LDL-C levels
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Index:
LILACS (Americas)
Main subject:
Cholesterol
/
Fatty Alcohols
/
Anticholesteremic Agents
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
1994
Type:
Article
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