Trypanosoma cruzi topoisomerase II: a target enzyme for the chemotherapy of Chagas' disease? Cloning and characterization of its encoding gene
Biol. Res
;
26(1/2): 77-80, 1993.
Article
in English
| LILACS
| ID: lil-228619
ABSTRACT
The study of Trypanosoma cruzi type II DNA-topoisomerase should provide new clues for the rational development of new drugs for the chemotherapy of Chagas' disease. This enzyme is very likely involved in the processes leading to T. cruzi replication and differentiation since both processes are blocked by bacterial type II DNA topoisomerase inhibitors. In this article, we review and discuss our recent data related to the cloning, sequencing, and expression of T. cruzi type II topoisomerase
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Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
Genes, Protozoan
/
DNA Topoisomerases, Type II
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
1993
Type:
Article
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