Bacterial chemistry. VI. Biological activities and cytotoxicity of 1, 3-dihydro-2H-indol-2-one derivatives
Biol. Res
;
25(1): 21-5, 1992. ilus, tab
Article
in English
| LILACS
| ID: lil-228630
RESUMO
The biosynthetic pigment from Chromobacterium violaceum BB-78, 1,3-dihydro-2H-indol-2-one and its derivatives exhibit biological activities such as antimicrobial action, low hemolytic effects on red blood cells and in vitro trypanocide activity. A relatively high cytotoxicity on V-79 hamster fibroblast cells of the biosynthetic pigment was found, although with the methylol derivative the toxicity was almost eliminated. The methylol derivative exhibited similar toxicity as Nifurtimox, a known, commercial trypanocide compound
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Index:
LILACS (Americas)
Main subject:
Pigments, Biological
/
Chromobacterium
/
Hemolysis
/
Indoles
/
Anti-Bacterial Agents
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
1992
Type:
Article
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