Role of Lysosomes on human ulcerogenic gastropathies. Effect of zinc ion on the lysosomal stability
Arq. gastroenterol
;
35(4): 247-51, out.-dez. 1998. graf
Article
in English
| LILACS
| ID: lil-229377
RESUMO
Numerous conditions are involved in the equilibrium between protective and aggressive factors for gastric mucosa injuring. Among them the lysosomal membrane stability plays a very important role in the inflammatory process. Zinc ion is a well-known lysosomal membrane stabilizer. When given orally to animals or even to humans it protects gastric mucosa against erosive lesions induced by a variety of experimental conditions. Compared with the control group (8,45 + 1,49 mU/mg) the lysosomes isolated from samples of gastric mucosa obtained from patients suffering of erosive gastropathies, showed a great liability on their membrane (18,37 + 4,52 mU/mg). When these patients were treated orally with zinc sulfate (100 mg of zinc element, twice a day, for two weeks) the lysosomes isolated from their gastric mucosa showed a strong reduction on enzymatic activity (5,49 + 1,02 mU/mg), probably due to increasing on the membrane stability. Based on these experimental findings we propose the use of zinc ion as na important adjuvant in treatment of erosive gastropathies.
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Index:
LILACS (Americas)
Main subject:
Stomach Ulcer
/
Zinc
/
Gastric Mucosa
/
Lysosomes
Limits:
Humans
Language:
English
Journal:
Arq. gastroenterol
Journal subject:
Gastroenterology
Year:
1998
Type:
Article
Affiliation country:
Brazil
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