Niveles de homocisteína en adultos sanos chilenos / Serum homocysteine levels in healthy chilean adults
Rev. méd. Chile
;
126(8): 905-10, ago. 1998. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-232935
ABSTRACT
Background:
Hyperhomocysteinemia is a newly recognized cardiovascular risk factor that is present in 10 to 20percent of European and North American individuals.Aim:
To measure homocysteine levels in healthy adults in Chile. Subjects andmethods:
Serum homocysteine levels were measured in healthy adults using a fluorimetric HPLC method. Folic acid, vitamin B12, serum lipids, creatinine and glucose were also assessed. All subjects answered a dietary habits questionnaire.Results:
One hundred twenty eight subjects (90 female) aged 22 to 78 years old were studied. Homocysteine levels were 9.7 ñ 6.0 and 7.0 ñ 3.1 µmol/l in men and women respectively (p< 0.001). Folic acid levels were 6.1 ñ 2.7 and 6.1 ñ 2.9 ng/ml in men and women, and 24percent of individuals had values below 4 ng/ml. Vitamin B12 levels were 393 ñ 147 and 393 ñ 163 pg/ml in the same groups. There was a negative correlation between homocysteine and folic acid levels and a positive correlation between homocysteine and creatinine levels.Conclusions:
Homocysteine levels in healthy Chilean individuals are similar to those reported abroad. Low folic acid levels were found in 24percent ofsubjects:
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Index:
LILACS (Americas)
Main subject:
Homocysteine
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
1998
Type:
Article
/
Project document
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