Batch cultivation kinetics of Neisseria meningitidis (Serogroup) in Frantz medium. I. growth and polysaccharide production
Arq. biol. tecnol
;
39(1): 215-220, mar. 1996. tab, graf
Article
in English
| LILACS, SES-SP
| ID: lil-233624
RESUMO
Polysaccharide of N. meningitidis serogroup C constitutes the antigen for the production of the specific vaccine against this serogroup. The production kinetics of polysaccharide (serogroup C) was studies in five cultivations carried out in an 80 L fermenter (total capacity), under the following process conditions Frantz medium; temperature 35§C; air flow 5 L.min-1 (o.125 vvm); agitation frequency 120 rpm and vessel pressure 6 psi. Global yeld factors and ield coefficients were calculated. It was observed two distinguished polysaccharide production phases growth associated and a growth non-associated. The cell productivity was about 0.11 (g drymass. L -1.h-1) and polysaccharide productivity near 7.0 (mg polysac. L-1. h-1)(AB)
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Index:
LILACS (Americas)
Main subject:
Polysaccharides
/
Vaccines
/
Meningitis
/
Neisseria
Language:
English
Journal:
Arq. biol. tecnol
Year:
1996
Type:
Article
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