Search for antifungal and anticancer compounds from native plant species of Cerrado and Atlantic Forest
An. acad. bras. ciênc
;
71(2): 181-7, jun. 1999. tab, ilus
Article
in English
| LILACS
| ID: lil-234512
ABSTRACT
Bioactivity-guided fractionation of several bioactive exttracts obtained from Cerrado and Atlantic Forest plant species led to the isolation of potent DNA-damaging piperidine 1-5 and guanidine alkaloids 6-9 from Cassia leptophylla and Pterogyne nitens respectively, two common Leguminosae from Atlantic Forest. By means of biotechnological approach on Maytenus aquifolium, a species from Cerrado, moderate DNA-damaging sesquiterpene pyridine alkaloid 10-11 was isolated. Bioassay-guided fractionation on Casearia sylvestris, a medicinal plant species found in Cerrado and Atlantic Forest, led to the isolation of clerodane diterpenes 12-13 which showed effect on DNA. In addition, we have reported several interesting potent antifungal iridoids 1beta-hydroxy-dihydrocornin (14), 1alpha-hydroxy-dihydrocornin (15), alpha-gardiol (16), beta-gardiol (17), plumericin (18), isoplumericin (19), 11-O-trans-caffeoylteucrein (20); ester derivative2-methyl-4-hydroxy-butyl-caffeoate (21), amide N-[7-(3ï, 4ï-metrylenedioxyphenyl)-2Z, 4Z-heptadienoyl] pyrrolidine (22) and triterpene viburgenin (23).
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Index:
LILACS (Americas)
Main subject:
Plants, Medicinal
/
Antifungal Agents
/
Antineoplastic Agents
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
An. acad. bras. ciênc
Journal subject:
Science
Year:
1999
Type:
Article
/
Congress and conference
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