Angiogenesis: characterization of a cellular model
P. R. health sci. j
;
17(4): 327-33, Dec. 1998.
Article
in English
| LILACS
| ID: lil-234846
RESUMO
Endothelial cell proliferation and differentiation into blood capillaries (i.e., angiogenesis) are essential for growth and development, wound healing, osetogenesis, etc. But abnormal angiogenesis during tumor progression could lead to serious consequences. Angiogenesis is a complex biochemical process, and is often difficult to study the molecular mechanism in vivo due to interference by multitude of factors. Here, I present a non-transformed capillary endothelial cell line as a model which has been extensively characterized morphologically and biochemically to study the fundamentals of the angiogenic process. Studies completed in our laboratory also evidenced that expression of Glc3Man9GlcNAc2-PP-Dol is intricately connected with the balance between the cellular proliferation and apoptosis during angiogenesis.
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Index:
LILACS (Americas)
Main subject:
Capillaries
/
Endothelium, Vascular
/
Neovascularization, Physiologic
/
Angiogenesis Inhibitors
/
Models, Biological
Type of study:
Prognostic study
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
P. R. health sci. j
Journal subject:
Medicine
Year:
1998
Type:
Article
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